The game is based in a post-apocalyptic world situated within the areas of Nevada, California and Arizona. The player takes control of a character only known as The Courier, who has been hired by the Mojave Express, a delivery company based in the Nevada desert, to deliver a unknown package to the New Vegas Strip. The Courier's delivery is interrupted by a mysterious man who ends up killing the player with a shot to the head as well as stealing the mysterious package. After having been dumped in a shallow grave, the player is found by a friendly local robot named Victor. The Courier is taken to the small town of Goodsprings to be healed by a man named Doc Mitchell.